Sermorelin & Ipamorelin Blend (10mg)

Sermorelin Specifications

Molecular Formula: C149H246N44O42S

Molecular Weight: 3357.9 g/mol

Sequence: Tyr-Ala-Asp-Ala-lle-Phe-DL-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

Ipamorelin Specifications

Molecular Formula: C38H49N9O5

Molecular Weight: 711.85 g/mol

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2

Sermorelin & Ipamorelin Peptide Blend Research

Sermorelin & Ipamorelin Blend and GHRH Receptors

Combinatorial research concerning Sermorelin & Ipamorelin peptides posits that there may be a synergistic potential to induce maximal release of endogenous growth hormone when different pituitary receptors are activated simultaneously. Sermorelin is a growth hormone-releasing hormone (GHRH) analog. This peptide is purported to be the shortest sequence that might activate the GHRH receptors. Sermorelin’s approximate half-life is thought to be between 11 and 12 minutes. Test models have suggested relatively rapid turnover.[1, 2] This peptide is composed of the initial 29 amino acids out of the usual 44 amino acids present in GHRH.

Despite Sermorelin’s truncated amino acid structure, it is hypothesized that Sermorelin might interact with GHRH receptors. This may trigger periodic growth hormone emissions.[3] It is theorized that Sermorelin might initiate various intracellular signaling events upon engaging with these receptors. One proposed pathway is the adenylyl cyclase pathway, which may facilitate the conversion of ATP (adenosine triphosphate) to cAMP (cyclic adenosine monophosphate).[4] An increase in cAMP levels may activate protein kinase A (PKA), which might, in turn, phosphorylate several proteins, such as the voltage-dependent calcium channels in the cell membrane.

It is speculated that the phosphorylation and possible subsequent opening of these calcium channels may allow calcium ions to enter the somatotroph cells. The resultant rise in intracellular calcium levels is thought to be critical for the subsequent steps in growth hormone release. Researchers further hypothesize that elevated calcium levels inside the cell might stimulate the secretory vesicles within the somatotroph cells, which may potentially lead to the release of growth hormone into the bloodstream. The increase in growth hormone production is believed to potentially enhance levels of insulin-like growth factor-1 (IGF-1), which is considered to be involved in the anabolic actions of growth hormone.