CJC-1295 & Ipamorelin Blend (10mg)

CJC-1295 & Ipamorelin Peptide Blend

Ipamorelin is a growth hormone (GH) secretagogue that has been extensively studied in the diverse biological milieu. It is considered by researchers to be one of the most selective secretagogues and is an apparent agonist of the growth hormone/ghrelin secretagogue receptor.[1] This potential selectivity is attributed to the fact that Ipamorelin does not appear, in any way, to affect the secretion of other pituitary hormones. These include prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or Adrenocorticotropic hormone (ACTH). Ipamorelin appears to act via the molecular mimicry of the natural hormone ghrelin, which triggers and stimulates the release of the growth hormone.[2] This whole process may be regulated by a negative feedback mechanism, which may nullify any ancillary impacts of excess GH production. Researchers suggest that Ipamorelin may impact all physiological processes in which ghrelin is active. Based on their observations, researchers have suggested that Ipamorelin may improve bowel movement and gastric function, enhancing the development and repair of muscles, facilitating the release of insulin hormone from the pancreas, and stimulating the growth of bones. In addition to these potentials, Ipamorelin may also be involved in cellular repair and increased collagen production.[3] It has also been hypothesized that the peptide may act to improve cognitive function and sleep cycle regulation.

CJC-1295 (Mod GRF 1-29) is a synthetic analog of a naturally-occurring peptide hormone, somatocrinin. It is also suggested by researchers to potentially promote the release of GH via stimulation of the growth hormone-releasing hormone receptor.[4] They mainly suggest the peptide to induce secretion of the growth hormone in a pulsatile manner. Since this process also appears to be regulated via a negative feedback mechanism, the ancillary impacts typically associated with excessive growth hormone production appear to be avoided. The peptide has also been associated with high selectivity and a potential supportive influence on the development and growth of muscles, lean body mass, bone function, and insulin resistance.[5] Alba et al. reports that “mice [exposed] every 48 and 72h reached higher body weight and length than placebo … animals.” It is suggested to be involved in cellular repair and regeneration processes as well. More specifically, the researchers share that they conducted an additional investigation into the potential of CJC-1295 on a murine model of GHRH gene ablation (GHRHKO) and related growth decline. It was hypothesized that the CJC-1295 group displayed apparently normal body weight and length, which potentially indicates a positive growth response. When evaluating the possible impact of CJC-1295 on bone length and body composition, the femur and tibia length appeared to remain within normal ranges, as well as lean mass and subcutaneous fat mass. Further analysis revealed that CJC-1295 influence potentially led to an increase in total pituitary RNA and GH mRNA levels. This may possibly suggest that the introduction of the peptide may have caused a proliferation of somatotroph cells, which are the natural cells with GH-producing potential in the pituitary gland. The hypothetical presence of these proliferating cells was suggested through immunohistochemistry images. CJC-1295 has also been suggested to support the immune system and cognitive function. Research on animal systems has indicated that combinatorial introduction of CJC-1295 & Ipamorelin blend appear to influence the growth hormone axis through two different pathways.