CJC-1295 & GHRP-6 Blend (10mg)

CJC-1295 & GHRP-6 Peptide Blend

The CJC-1295 & GHRP-6 blend have been posited by researchers to display a synergistic action on cells that participate in the release of growth hormone. More specifically, the mix includes CJC-1295, which appears to be similar in action to growth hormone-releasing hormone (GHRH), and GHRP-6 (Growth Hormone Releasing Peptide 6), which appears to bind to the receptors of the hunger hormone ghrelin.This combination of peptides may possibly increase both the strength and the number of growth hormone signals from somatotroph cells. CJC-1295 appears to target the GHRH receptor pathway, while GHRP-6, is considered by researchers to act on the ghrelin receptor pathway. This may explain why the combination of CJC-1295 and GHRP-6 exhibits potential to interact with somatotroph cells in the pituitary gland and the hypothalamus. Both of these regions in the central nervous system are considered to be comprised of cells that are believed to be important in making and controlling growth hormone synthesis.

CJC-1295 (Mod GRF 1-29) Specifications

Molecular Formula: C152H252N44O42

Molecular Weight: 3647.954 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2

Note: DOES NOT CONTAIN DAC

GHRP-6 Specifications

Molecular Formula: C46H56N12O6

Molecular Weight: 873.032 g/mol

Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys

CJC-1295 & GHRP-6 Blend Research

CJC-1295 (Mod GRF 1-29), or tetra-substituted GRF (1-29), is a synthetically developed peptide equivalent to the naturally occurring GHRH hormone. It includes the smallest possible chain of amino acids that might connect to the GHRH receptors, and comprises the initial 29 amino acids of GHRH. The primary structural differences between CJC-1295 and its naturally occurring GHRH equivalent lies in 4 substituted amino acids of GHRH’s original 29 amino acids, to possibly enhance the peptide’s resistance to breakdown by the enzyme dipeptidyl peptidase-4. More specifically, the amino acids that have been altered and substituted are the 2nd, 8th, 15th, and 27th amino acids.[1] Further, the researchers commented, “CJC-1295 caused an increase in total pituitary RNA and GH mRNA, suggesting that proliferation of somatotroph cells had occurred, as confirmed by immunohistochemistry images.” CJC-1295 appears to bind to and interact with the receptor of GHRH in the anterior pituitary gland.[2] It may potentially maintain the pulsatile production of growth hormone (GH), improving overall physiological levels.

GRHP-6, on the other hand, is an opioid analog of the peptide Met-enkephalin. Yet, researchers suggest it lacks the opioid activity generally associated with these enkephalins.[3] GHRP-6 is a synthetic hexapeptide that researchers have categorized as a hormone-releasing peptide. It has been suggested to exhibit action by possibly attaching to the ghrelin receptor found on pituitary cells and specific neurons in the hypothalamus. When it binds, GHRP-6 appears to activate what is known as the growth hormone secretagogue receptor (GHS-R1a). Thus, it has been studied concerning its interaction with the growth hormone secretagogue receptor. GHRP-6 appears to act by the molecular mimicry of the hormone ghrelin, potentially causing a stimulation of the growth hormone secretion. Since growth hormone receptors are present in many cells, the impact of GHRP-6 may be widespread.[4]